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CAS NO. : 497-30-3
Appearance: White Powder
Ergothioneine, particularly in the form of L-Ergothioneine (CAS number 497-30-3), can protect the DNA and mitochondria of skin cells, playing a crucial antioxidant and anti-aging role. This powerful compound, available as an ergothioneine supplement or L-Ergothioneine powder, helps reduce pigmentation and fine lines while improving skin moisture content and elasticity. As a trusted L-Ergothioneine supplier, Yanggu Huatai provides top-tier ergothioneine supplements that deliver these remarkable skin benefits, making it a valuable addition to any skincare regimen.
appearance | White solid |
water content | ≤0.5% |
Ignition residue | ≤0.5% |
Related substance | single impurity≤0.5%; total impurities≤1.0% |
Heavy metal | HG≤1mg/kg |
AS≤2mg/kg | |
CD≤5mg/kg | |
PB≤10mg/kg | |
Total plate count | ≤100CFU/g |
Assay(HPLC) | 98.0-102.0% |
Purity | ≥99.0% |
L-Ergothioneine (EGT) is a naturally occurring sulfur-containing amino acid with a unique chemical structure. First isolated from ergot fungus in 1909, this compound is primarily found in certain fungi, bacteria, and dietary sources such as mushrooms. Interestingly, L-Ergothioneine is also present in human tissues and organs, including red blood cells, bone marrow, liver, kidneys, and eyes. However, the human body cannot synthesize it on its own and must obtain it through dietary intake.
L-Ergothioneine is renowned for its potent antioxidant properties, which help neutralize free radicals and chelate various divalent metal cations. It also interacts with the body’s natural antioxidant defense systems, providing anti-inflammatory and cell-protective effects. These benefits have led to its widespread application in food, medicine, and cosmetics.
1909: L-Ergothioneine was first isolated from ergot fungus.
1911: Scientists determined its structure, confirming it as a derivative of histidine betaine.
Mid-20th Century: Due to limited research, it was mistakenly believed to be inert to the human body.
2005: The discovery of the exclusive transporter OCTN1 reignited research interest in EGT.
2009: Studies demonstrated its effectiveness in skincare applications.
2014: The ingredient was included in the Catalogue of Used Cosmetic Raw Materials issued by the China Food and Drug Administration.
2017: Approved as a novel food ingredient in Europe.
2019: Achieved GRAS (Generally Recognized as Safe) certification from the US FDA, and Japan introduced functional foods containing EGT.
2021: Japan approved EGT for use in healthcare products and general foods.
Since then, L-Ergothioneine has gained global attention as a valuable functional ingredient, attracting major brands and consumers alike.
There are three primary methods for producing L-Ergothioneine:
1. Natural Extraction: While this method involves isolating EGT from natural sources like mushrooms, it has limitations, including low yield, high levels of impurities, and challenges in obtaining high-purity products.
2. Chemical Synthesis: Although capable of producing EGT, chemical synthesis is complex, involves long production routes, generates multiple by-products, and is expensive.
3. Fermentation: The fermentation method, a biotechnological process, has emerged as the most cost-effective and scalable solution for producing high-purity L-Ergothioneine. It is considered safe and suitable for large-scale production.
L-Ergothioneine is a water-soluble amino acid that requires the OCTN1 transporter to be delivered to tissues and organs, such as red blood cells, bone marrow, liver, kidneys, and eyes.
As a membrane-impermeable molecule, L-Ergothioneine relies on the OCTN1 transporter to cross cell membranes. This transporter is abundantly expressed in tissues such as the kidneys, trachea, bone marrow, and skeletal muscle. Additionally, mitochondria contain OCTN1, allowing EGT to enter and exert its antioxidant effects efficiently.
Antioxidant Properties: L-Ergothioneine neutralizes free radicals, protects DNA, supports normal cell growth, and slows aging processes.
Anti-Inflammatory and Anti-Acne: Research indicates that EGT reduces inflammation in skin cells, making it effective in treating acne.
Anti-Aging: With its strong antioxidant capacity, EGT delays aging, reduces protein glycation, and enhances skin elasticity. It can also improve facial contours and reduce the appearance of orange-peel-like textures.
Whitening Effects: By inhibiting pigmentation and melanin deposition, EGT helps brighten and whiten the skin.
Sunscreen Properties: EGT minimizes reactive oxygen species formation and protects cells from UV-induced damage. It is commonly added to skincare formulations for outdoor protection.
Synergistic Effects: EGT enhances the efficacy of other active ingredients in skincare products by regulating redox reactions and cellular energy.
Mitochondrial Protection: EGT protects mitochondria from oxidative damage, effectively reducing aging at the cellular level.
Anti-Glycation: It reduces the formation of advanced glycation end-products (AGEs), maintaining skin elasticity and promoting skin health.
Anti-Photoaging: EGT prevents UV-induced lipid peroxidation and inflammation, offering robust protection against photoaging.
DNA Damage Prevention: EGT guards against mitochondrial DNA damage, preserving cell functionality and skin health.
These properties make L-Ergothioneine a popular ingredient in skincare products, particularly anti-aging and sunscreen formulations.
Eye Protection: Reduces oxidative stress in ocular tissues.
Cardiovascular Health: Protects heart tissues from oxidative damage.
Muscle Repair: Promotes muscle recovery and reduces oxidative damage after exercise.
Anti-Inflammatory: Reduces inflammation throughout the body.
Neurodegenerative Disease Prevention: L-Ergothioneine can cross the blood-brain barrier, regulating neuronal differentiation and neurogenesis. Studies suggest that long-term supplementation may help prevent neurodegenerative diseases, including Alzheimer's and Parkinson's.
Currently, no significant adverse effects of L-Ergothioneine have been reported at dietary or supplement levels. However, as with any supplement, it's essential to adhere to recommended dosages and consult a healthcare professional if uncertain.
Finding a reliable supplier for high-quality L-Ergothioneine powder or supplements is crucial to ensure superior product standards, innovation, and excellent customer support. Yanggu Huatai emerges as a trusted choice for all your L-Ergothioneine requirements.
Yanggu Huatai partners with universities and research organizations to advance the development of dietary supplements, food additives, and wellness technologies. These partnerships ensure the company stays at the forefront of scientific innovation and delivers the highest quality L-Ergothioneine products to its clients.
Customer satisfaction is at the heart of Yanggu Huatai's operations. The company offers 24/7 technical and after-sales support through a dedicated team, ensuring prompt responses to inquiries about technical specifications, product details, and order management for a smooth customer experience.
To cater to various customer needs, Yanggu Huatai provides flexible packaging options for its L-Ergothioneine powder and supplements. With established partnerships with reliable logistics providers, the company ensures the safe and timely global delivery of products by air or sea.
Yanggu Huatai boasts an expert R&D team dedicated to continuous innovation, particularly in dietary supplements like L-Ergothioneine. This ongoing investment in research strengthens the company's position as an industry leader, offering clients cutting-edge products designed to meet their specific needs.
As a reliable L Ergothioneine manufacturer, the company upholds rigorous quality control measures to guarantee that all products adhere to international safety and purity standards. From sourcing raw materials to final production, Yanggu Huatai's attention to detail ensures consistent product excellence.
Yanggu Huatai's commitment to quality, innovation, and customer satisfaction makes it an outstanding partner for your L-Ergothioneine sourcing needs. Choose a supplier that delivers premium products and prioritizes your business success.
Cheah, I. K., & Halliwell, B. (2012). Ergothioneine; antioxidant potential, physiological function, and role in disease. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.
FDA GRAS Notice No. GRN 000734 for L-Ergothioneine.
Scientific Opinion on the safety of L-Ergothioneine as a novel food ingredient by EFSA (2017).
Ames, B. N., et al. (2019). Supplementation of L-Ergothioneine and its benefits in aging and neurodegenerative diseases. The Journal of Nutrition.
EFSA Journal (2017). Novel Food Approval for L-Ergothioneine.
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