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CAS NO. : 1077-28-7/62-46
Alpha lipoic acid is a coenzyme present in mitochondria, similar to vitamins, that can eliminate free radicals that accelerate aging and disease. Lipoic acid is absorbed through the intestines and enters cells, possessing both lipid and water-soluble properties. Therefore, alpha lipoic acid antioxidant can travel freely throughout the body and reach any cellular site, providing comprehensive efficacy for the human body. It is a versatile antioxidant with both lipid and water-soluble properties. As one of the leading alpha lipoic acid manufacturers, Yanggu Huatai provides high quality ala dietary supplement. Explore now!
Molecular Formula | C８H14O2S2 |
Molecular Mass | 206.33 |
Appearance | Slightly yellow granular |
Melting Point | 60.0~62.0°C |
Specific rotation | -1.0°~+1.0° |
Loss on drying | ≤0.2% |
Residue on Ignition | ≤0.1% |
Heavy Metals | ≤10ppm |
Assay (dried basis) | 98.5%~101.0% |
Chromatographic purity | Iingle Impurities≤0.1%, Total Impurities≤2.0% |
Particle Size | 100% through 20 mesh |
Package and Storage Condition | 25kg/ drum, store and seal away from light |
Shelf life | 2 years |
Alpha lipoic acid dietary supplement has both water solubility and lipid solubility, and can penetrate the blood-brain barrier and penetrate various parts of cells;
Ala antioxidant exhibits reversible coexistence of oxidation-reduction states, comprehensive elimination of free radicals, double antioxidant capacity;
Alpha lipoic acid ala supplement can restore other antioxidants.
ALA antioxidant is one of the most powerful antioxidant. Antioxidant lipoic acid has both lipid and water solubility. Lipoic acid belongs to the vitamin B group and has functions such as clearing free radicals and reactive oxygen species (antioxidants), chelating metal ions, and regenerating other antioxidants. Therefore, ala food supplement or ala nutrition supplement is widely used and has extremely high health functions and medical value.
R-ALA (R-alpha-lipoic acid) is a powerful antioxidant that enhances the body’s natural defenses. Once inside cells, ALA is converted to dihydrolipoic acid (DHLA), which amplifies its antioxidant activity and bioavailability. It helps modulate cellular stress response pathways, increasing the body’s overall antioxidant capacity. This enhanced antioxidant function aids in reducing inflammation and fortifies cellular defenses against oxidative stress and environmental pathogens. Furthermore, R-ALA has been shown to elevate glutathione levels, a critical component of the body’s natural detoxification and antioxidant systems.
The antioxidant properties of ALA may provide significant benefits for skin health. By scavenging harmful free radicals, ALA helps protect skin cells from damage caused by oxidative stress and UV radiation. It may also enhance the production of glutathione, which can reduce visible signs of aging such as fine lines and wrinkles. These effects make ALA a popular ingredient in skincare products aimed at improving skin texture, tone, and overall appearance.
Alpha lipoic acid may assist in weight management by influencing metabolic processes. Research indicates that ALA can reduce the activity of AMP-activated protein kinase (AMPK) in the hypothalamus, which may help suppress appetite. Additionally, ALA boosts mitochondrial activity, promoting calorie burning at rest. While studies show modest weight-loss effects, ALA supplementation is most effective when paired with a healthy diet and regular exercise.
R-ALA provides various additional health benefits, including:
Cognitive Function: Its antioxidant properties protect brain cells from oxidative damage, supporting cognitive health and memory retention.
Nerve Health: ALA is particularly beneficial for improving nerve function in individuals with diabetic neuropathy. Studies show that when combined with physical therapy, ALA can significantly alleviate nerve pain and improve overall nerve health.
ALA supplements are generally well-tolerated, with minimal risk of side effects. However, some individuals may experience mild symptoms such as nausea, itching, or dizziness. Additionally, ALA may interact with medications that regulate blood sugar, potentially causing hypoglycemia. It is advisable to consult a healthcare professional before starting any new supplement, particularly for individuals with underlying health conditions or those on prescription medications.
Both Alpha Lipoic Acid (ALA) and Alpha Lipoic Acid R Lipoic Acid (R-ALA) are potent antioxidants, but their differences lie in structure, bioavailability, and efficacy. R-ALA is the naturally occurring and biologically active form of ALA, offering superior potency, stability, and effectiveness due to its higher bioavailability. Detailed comparison of their characteristics is as follows:
| Feature | Alpha Lipoic Acid (ALA) | R Alpha Lipoic Acid (R-ALA) |
CAS Number | 1077-28-7 | 1200-22-2 |
Other Names | Thioctic Acid | R-Thioctic Acid |
Molecular Formula | C₈H₁₄O₂S₂ | C₈H₁₄O₂S₂ |
Molecular Weight | 206.32 g/mol | 206.32 g/mol |
Appearance | Yellow crystalline powder | Yellow crystalline powder |
Purity | ~99% | >99% (high-purity R-isomer) |
Bioavailability | Moderate (due to S-isomer) | High (R-isomer is bioactive) |
Potency | Lower (mixture of R and S isomers) | Higher (pure bioactive form) |
Half-life | Short (~30 minutes) | Longer (~1-2 hours) |
Stability | Less stable in heat and moisture | More stable in optimized formulations |
Popularity | Widely used due to affordability | Gaining popularity in targeted uses |
Pricing | Affordable | More expensive (~2-3x ALA cost) |
Functionality | General antioxidant benefits | Superior cellular and metabolic activity |
Usage | Dietary supplements | Premium dietary supplements and research |
Isomer Composition | 50% R-isomer + 50% S-isomer | 100% R-isomer |
Potency and Effectiveness: R-ALA is the biologically active form and demonstrates significantly higher antioxidant activity compared to standard ALA, which contains a mixture of R- and S-isomers. The S-isomer in ALA is considered inactive and may even reduce the effectiveness of the R-isomer.
Bioavailability: R-ALA is absorbed more efficiently by the body, leading to better utilization and results at lower doses. Studies indicate that R-ALA’s bioavailability and metabolic support far exceed those of racemic ALA (standard ALA).
Stability: R-ALA is more stable when formulated correctly, while ALA is prone to degradation under heat and moisture, which can reduce its efficacy.
Cost: R-ALA is more expensive due to its purity and effectiveness. It often costs 2-3 times more than standard ALA but delivers greater health benefits.
As one of the leading alpha lipoic acid manufacturers, Yanggu Huatai prioritize compliance and thorough documentation for our bulk Alpha Lipoic Acid. Our dedicated quality assurance team is always ready to provide essential safety data sheets, certifications, and any other compliance documents you may require. We understand the critical importance of maintaining accurate and up-to-date documentation for every ingredient, including Alpha Lipoic Acid. With our thorough documentation, you can be confident that compliance-related delays will no longer disrupt your production. Choose Yanggu Huatai for your Alpha Lipoic Acid requirements and experience a smooth, hassle-free production process in our alpha lipoic acid factory.
At Yanggu Huatai, we pride ourselves on delivering unmatched product quality and exceptional service. Trust us to supply premium Alpha Lipoic Acid and enjoy the distinct advantages of working with a wholesale ingredient supplier dedicated to your success.
R-Alpha Lipoic Acid (R-ALA): The natural, bioactive form of ALA with superior potency and effectiveness, widely recognized for its role in managing blood sugar, oxidative stress, and energy metabolism.
Sodium R-Lipoate (Na-RALA): A stabilized salt of R-ALA, offering enhanced solubility, bioavailability, and stability, making it a popular choice for premium supplements.
Potassium R-Lipoate (K-RALA): Another stabilized salt form of R-ALA, ideal for liquid formulations and pharmaceutical applications.
Dihydrolipoic Acid (DHLA): The reduced form of ALA that acts as a powerful antioxidant, capable of regenerating other antioxidants such as glutathione and Vitamin C.
Polymeric Alpha Lipoic Acid (Poly-ALA): Known for its improved stability and controlled-release properties, commonly used in extended-release formulations.
ALA Ethyl Ester: This derivative features enhanced lipophilicity, allowing for better cellular absorption. It is frequently utilized in skincare products and lipophilic drug formulations.
Lipoamide: An amide derivative of ALA, mainly used in metabolic and enzymatic health applications.
Lipoic Acid Conjugates: Combinations of ALA with amino acids or peptides designed for targeted delivery and synergistic effects.
S-Alpha Lipoic Acid (S-ALA): A synthetic isomer of ALA that lacks bioactivity, commonly included in more cost-effective racemic formulations.
Most Popular Derivatives: R-ALA and its stabilized forms (Na-RALA, K-RALA) are highly preferred due to their exceptional bioavailability, stability, and effectiveness.
Yes, most ALA powder is derived from synthetic or plant-based sources, making it suitable for both vegans and vegetarians. In order to ensure compatibility, remember to check the product label.
High-quality ALA powder typically boasts a purity level of 99% or higher, ensuring its effectiveness and safety for use in dietary supplements, skincare products, and pharmaceuticals.
Yes, we offer free samples of our ALA powder, but customers are responsible for shipping costs. Sampling allows you to evaluate the quality and efficacy of our product. Simply provide your shipping details, and we will arrange for the sample delivery promptly.
We are a certified manufacturer specializing in Alpha Lipoic Acid production. With ISO9001 certification and years of experience, we ensure high-quality, reliable, and consistent products to meet your needs.
Packer, L., Witt, E. H., & Tritschler, H. J. (1995). "Alpha-lipoic acid as a biological antioxidant." Free Radical Biology and Medicine.
Shinto, L., et al. (2006). "The effect of antioxidants on skin and aging." Journal of Dermatology.
Koh, E. H., et al. (2011). "Effects of alpha-lipoic acid on AMPK signaling and glucose metabolism in humans." Molecular Metabolism.
Ziegler, D., et al. (2004). "Oral treatment with alpha-lipoic acid improves symptoms of diabetic polyneuropathy." Diabetes Care.
Ziegler, D., et al. (1995). "Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: Current evidence from clinical trials." European Journal of Pharmacology, 16(6), 90–95.
Gleiter, C. H., et al. (1995). "Clinical pharmacokinetics of alpha lipoic acid." Clinical Pharmacokinetics, 29(5), 329–346.
Smith, A. R., et al. (2004). "Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress." Pharmacological Research, 66(3), 58–70.
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